McCammon Group

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University of California, San Diego
For Visitors Dept. of Chemistry and Biochemistry Dept. of Pharmacology
Current Research
Most biochemical reactions occur in solution or at interfaces between lipid bilayers and aqueous phases. The McCammon group studies these reactions using principles of statistical mechanics, classical and quantum mechanical models, and homology models of proteins to gain insight into functions of biological macromolecules. Our research focuses on rational drug design, molecular simulations, and questions in structural biology. Our studies benefit from the excellent computing facilities to which we have access, including superb visualization tools, networks of high-performance personal computers, and parallel supercomputers.    
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University of California, San Diego
La Jolla, CA 92093-0365, USA 

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Research in the McCammon group is supported in part by grants from the following agencies:
National Science Foundation, National Institutes of Health, NSF Supercomputer Centers, Burroughs Wellcome Fund, Howard Hughes Medical Institute, W.M. Keck Foundation, Accelrys, Inc., and the University of California.

Image of FKBP-12 generated by InsightII (Accelrys, Inc.)
FKBP-12 is an important target for immunosuppressant drug design.
Ligands pictured are discussed in J.-H. Lin, A. Perryman, J. Schames, J. A. McCammon, J. Amer. Chem. Soc., 124, 5632 (2002).


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