Gallery of Biomolecule Simulations

Breathing of the channel
Breathing (gating) of the channel to the active site of acetylcholinesterase. The gating contributes to the specificity of action of the enzyme (``dynamic selectivity'') by greatly slowing the binding of substrates that are larger than the natural one.
Zhou, H.-X., S.T. Wlodek, J.A. McCammon. Conformation Gating as a Mechanism for Enzyme Specificity. Proc. Natl. Acad. Sci. USA 95, 9280-9283 (1998).
McCammon Group, UCSD - - created by Kaihsu Tai

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